KITORA's Blog Annex
BEYOND VIAGRA 
Well, I wanna introduce that might be a good news for
both male and female.
It's just a little old news, but still not common news
from Chemical & Engineering News[外部ﾘﾝｸ].
Chemical & Engineering News,July 28, 2003
Volume 81, Number 30, CENEAR 81 30 p. 9
ISSN 0009-2347
BEYOND VIAGRA
Arginase inhibitors touted as potential drug target
for sexual dysfunction
Summary of this article is
In the past few years, scientists have made strides in understanding the enzyme arginase’s role as a thwarter of penile erections. Now, a new study suggests arginase may also play a similar role in female sexuality.
It means like a VIAGRA for women might be on sale someday.
The researchers have detected signs of
arginase activity in the genitalia of
female rabbits, just as was previously
shown for genitalia in human males.
They also demonstrate that smooth-muscle
relaxation of the genitalia of live rabbits,
both male and female, increases with
administration of a small molecule that
inhibits arginase
[Biochemistry, 42, 8445 (2003)].
The results, the researchers say, point
to arginase II as a potential drug target
to treat female sexual dysfunction.
Until recently, the problem hasn't received
much attention. Now, researchers are
addressing the issue, but they say there's
still much to learn about how issues such as
blood flow affect problems unique to females,
such as pain or lack of lubrication.
For example, a 2001 study, conducted by
Mary Lake Polan, chairman of the Stanford
University obstetrics and gynecology department,
along with the company ArginMax, showed that
an arginine nutraceutical improved
the sex lives of women more than a placebo.
We know that the wildly popular drug Viagra has acquired
a reputation for inducing hardy erections in the most
fragile octogenarian, it doesn't do much for women.
But this is not a VIAGRA.
They also speculate that because NO synthase
is present in human clitoral tissue and the
vagina, perhaps arginase II also is there.
Following their success with rabbits,
Christianson says, the group hopes to test
the inhibitors in larger mammals, such as dogs.
They also plan to test the inhibitors' oral
bioavailability.
OK, the study goes to larger mammals level.
It might still take time. :-P
Irwin Goldstein, director of the Institute for
Sexual Medicine at Boston University, says that
although an arginase-targeting treatment likely
won't help the majority of female sexual problems,
which are desire- or pain-based, the new work is
"another part of a huge puzzle. The field of
female sexual dysfunction is just developing."
Well, let's say this is still a study-field no one gone before.
But we hope it will give both male and female a better life
in the near future.
News source is here[外部ﾘﾝｸ] (Need subscribe the journal)
Japanese Version of this Entry is here[外部ﾘﾝｸ]
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